The decisive feature of the race, which started in Mendrisio that year, was once again the Civiglio ascent: 2,200 metres, averaging 8%. At the summit, the finish line would still be 15 kilometres away.
After the break was over, ten riders – all the best ones – remained at the fore, including Di Luca, Bettini, Rebellin, Schleck, Moreni, Wegmann and Boogerd.
A little into the climb, Di Luca tried to break away, but was brought back swiftly by Rebellin and Wegmann.
Bettini caught everybody off guard when he put the hammer down, pushing the big gear and dropping his opponents on the way to the summit.
Di Luca sat up, suffering the blow. Rebellin continued along at a solid tempo, but was soon caught up by the chasing peloton.
Despite continuing to push, solo, along the descent leading to Como, Bettini was caught up by Wegmann in the short flat stretch before the closing ascent to San Fermo della Battaglia.